By John S. Bradley MD, John D. Nelson MD Emeritus, Dr. David W Kimberlin MD FAAP, Dr. John A.D. Leake MD MPH, Dr. Paul E Palumbo MD, Dr. Jason Sauberan PharmD, Dr. William J Steinbach
New twentieth Edition! This bestselling and universal source on pediatric antimicrobial remedy offers speedy entry to trustworthy, up to date options for therapy of all infectious illnesses in youngsters.
For each one affliction, the authors supply a remark to aid wellbeing and fitness care services opt for the easiest of all antimicrobial choices. Drug descriptions disguise all antimicrobial brokers to be had this day and contain entire information regarding dosing regimens. according to growing to be matters approximately overuse of antibiotics, this system comprises instructions on whilst to not prescribe antimicrobials.
Practical, evidence-based concepts from the specialists in antimicrobial remedy:
Developed through extraordinary editorial board
Designed if you happen to look after young ones and are confronted with judgements each day
Includes remedy of parasitic infections and tropical medicine.
Updated checks concerning the power of the advice and the point of facts for therapy thoughts for significant infections
Anti-infective drug directory, whole with formulations and dosages
Antibiotic treatment for overweight children
Antimicrobial prophylaxis/prevention of symptomatic infection
Maximal grownup dosages and better dosages of a few antimicrobials ordinary in children
Read or Download 2014 Nelson's Pediatric Antimicrobial Therapy PDF
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Additional resources for 2014 Nelson's Pediatric Antimicrobial Therapy
For Enterobacter, Serratia, or Citrobacter: ADD gentamicin IV, IM to cefotaxime or ceftriaxone, OR use cefepime or meropenem alone (AIII). indb 24 Ampicillin IV/IM AND gentamicin or cefotaxime IV/IM for 10 days; many neonatologists treat low-risk infants for 7 days or less (see Comments). Ampicillin IV, IM AND gentamicin IV, IM for 7–10 days (AIII) Azithromycin PO, IV q24h for 5 days OR erythromycin ethylsuccinate PO for 14 days (AII) Clindamycin PO, IV for 10 days (organisms are resistant to macrolides) Azithromycin 10 mg/kg PO, IV q24h for 5 days OR erythromycin ethylsuccinate PO for 14 days (AII) –– Empiric therapy of the neonate with early onset of pulmonary infiltrates (within the first 48–72 h of life) –– Aspiration pneumonia67 –– Chlamydia trachomatis68 –– Mycoplasma hominis69,70 –– Pertussis71 Association of erythromycin and pyloric stenosis in young infants; may also occur with azithromycin Alternatives for >1 mo of age, clarithromycin for 7 days, and for >2 mo of age, TMP/SMX for 14 days Pathogenic role in pneumonia not well defined and clinical efficacy unknown; no association with bronchopulmonary dysplasia (BIII).
Gram stain of expressed pus guides empiric therapy; vancomycin if MRSA prevalent in community; alternative to vancomycin: clindamycin, linezolid, may need surgical drainage to minimize damage to breast tissue Treatment duration individualized, until clinical findings have completely resolved (AIII) Continue gentamicin until clinical and microbiological response documented (AIII). Duration of therapy: 10 days for bacteremia/sepsis (AII); minimum of 14 days for meningitis (AII). If organism susceptible and infection not severe, oxacillin/ nafcillin or cefazolin are alternatives for methicillin-susceptible strains.
Indb 39 Empiric IV therapy: Standard: oxacillin/nafcillin 150 mg/kg/day IV div q6h OR cefazolin 100 mg/kg/day IV div q8h (BII) CA-MRSA: clindamycin 30 mg/kg/day IV div q8h OR vancomycin 40 mg/kg/day IV q8h (BII) For oral therapy for MSSA: cephalexin (AII) OR amox/ clav 45 mg/kg/day PO div tid (BII); for CA-MRSA: clindamycin (BII), TMP/SMX (CIII), or linezolid (BII) Cefotaxime 100–150 mg/kg/day IV div q8h OR ceftriaxone 50 mg/kg/day (AI) IV, IM q24h; for 2–7 days parenteral therapy before switch to oral (BII) Penicillin G 100,000–200,000 U/kg/day IV div q4–6h (BII) initially then penicillin V 100 mg/kg/day PO div qid or tid OR amoxicillin 50 mg/kg/day PO div tid for 10 days Cellulitis of unknown etiology (usually S aureus, including CA-MRSA, or group A streptococcus)1–7,21 Cellulitis, buccal (for unimmunized infants and preschool-aged children, H influenzae type b)22 Cellulitis, erysipelas (streptococcal)1,2,7 These dosages may be unnecessarily large, but there is little clinical experience with smaller dosages.