By John S. Bradley, John D. Nelson et al. (eds.)
New twenty first Edition! This bestselling and time-honored source on pediatric antimicrobial therapy offers immediate entry to trustworthy, up to the moment innovations for therapy of all infectious illnesses in youngsters.
Practical, evidence-based ideas from the specialists in antimicrobial therapy
- Developed via exclusive editorial board
- Designed should you look after young children and are confronted with judgements each day
- New at-a-glance tables of bacterial and fungal pathogen susceptibilities to typical antimicrobials
- New info on neonatal developmental pharmacology
- Includes remedy of parasitic infections and tropical medicine
- Updated tests concerning the power of the advice and the extent of facts for remedy strategies for significant infections
- Anti-infective drug directory, entire with formulations and dosages
- Antibiotic treatment for overweight children
- Antimicrobial prophylaxis/prevention of symptomatic infection
- Maximal grownup dosages and better dosages of a few antimicrobials typical in children
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Extra resources for 2015 Nelson's Pediatric Antimicrobial Therapy
Clinicians may administer palivizumab prophylaxis in the first year of life to certain infants with hemodynamically significant heart disease. Aerosol ribavirin (6-g vial to make 20-mg/mL solution in sterile water), aerosolized over 18–20 h daily for 3–5 days (BII), provides little benefit and should only be used for life-threatening infection with RSV. Difficulties in administration, complications with airway reactivity, and concern for potential toxicities to health care workers preclude routine use.
Antimicrobial Therapy According to Clinical Syndromes 2015 Nelson’s Pediatric Antimicrobial Therapy — 43 Empiric therapy: Standard: oxacillin/nafcillin 150 mg/kg/day IV div q6h OR cefazolin 100 mg/kg/day IV div q8h (AI), OR cephalexin 50–75 mg/kg/day PO div tid CA-MRSA: clindamycin 30 mg/kg/day IV or PO div q8h OR vancomycin 40 mg/kg/day IV q8h (BII) CSD: azithromycin 12 mg/kg once daily (max 500 mg) for 5 days (BIII) 6 12/19/14 3:39 PM Adenitis, acute bacterial1–7 (S aureus, including CA-MRSA, and group A streptococcus; consider Bartonella [CSD] for subacute adenitis)8 6 A.
Increase to 50 mg/kg/dose for meningitis. Initial loading dose of 18 div q12h on day 1. Desired serum concentrations, trough 2–6 µg/mL. q Starting dose if gestational age <35+0 wk and postnatal ≤14 days. See Table A HIV for zidovudine dosage after 2 weeks of age and for NVP and 3TC recommendations. n o p C. 5 mg/kg q24h (see Chapter 11). Desired serum concentrations: 20–35 mg/L (peak), <7 mg/L (trough). Desired serum concentrations: 5–10 mg/L (peak), <2 mg/L (trough). 6 >28 wk Dose 15 20 15 10 15 Frequency q12h q24h q24h q24h q48h Serum creatinine concentrations normally fluctuate and are partly influenced by transplacental maternal creatinine in the first week of age.