By Martin D. Abeloff MD, James O. Armitage MD, Joel E. Tepper MD, John E. Niederhuber MD, James H Doroshow, Michael B. Kastan MD PhD, W. Gillies McKenna MD PhD, Daniel von Hoff Daniel Von Hoff M.D. F.A.C.P.
Wearing at the culture validated by way of its founding editor, the overdue Dr. Martin Abeloff, the 4th version of this revered reference synthesizes the entire most recent oncology wisdom utilizing a pragmatic, clinically centred, easy-to-use technique. It comprises simple technology, pathology, analysis, administration, results, rehabilitation, and prevention multi functional handy source - equipping you to beat your hardest scientific demanding situations. what is extra, you could entry the total contents of this specialist seek advice top rate version on-line, plus typical updates to maintain your perform present . . . board-style self-assessment questions . . . downloadable illustrations . . . and plenty of different complicated beneficial properties that make it much more integral to your practice!Equips you to pick the main acceptable exams and imaging experiences for diagnosing and staging every one kind of melanoma, and deal with your sufferers such a lot successfully utilizing the entire most modern approaches.Explores the entire most modern medical discoveries' implications for melanoma prognosis and management.Employs a multidisciplinary technique - with contributions from pathologists, radiation oncologists, clinical oncologists, and surgical oncologists - for well-rounded views at the difficulties you face.Offers a ordinary format with a constant bankruptcy structure . precis containers . a full-color layout . and greater than 1,445 illustrations (1,200 in complete color), to make reference effortless and efficient.Offers entry the book's entire contents on-line - absolutely searchable - from wherever with an online connection.Features ordinary updates on-line to mirror vital new discoveries and scientific directions, plus downloadable illustrations, board-style self-assessment questions, and plenty of different complicated on-line features.Presents discussions on state-of-the-art new subject matters together with nanotechnology, sensible imaging, sign transduction inhibitors, hormone modulators, issues of transplantation, and lots more and plenty extra. contains an increased colour paintings software that highlights key issues, illustrates correct technological know-how and medical difficulties, and complements your figuring out of advanced concepts.Your buy entitles you to entry the website till the subsequent variation is released, or till the present version isn't any longer provided on the market by means of Elsevier, whichever happens first. If the following variation is released below 365 days after your buy, you can be entitled to on-line entry for 12 months out of your date of buy. Elsevier reserves the best to supply an appropriate alternative product (such as a downloadable or CD-ROM-based digital model) should still entry to the website be discontinued.
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Additional resources for Abeloff's Clinical Oncology, 4th Edition
Dimerization is thus achieved by interactions between the receptor and the ligand. 21,22 Regardless of how the extracellular domains are brought into close apposition, the result is the juxtapositioning of the two catalytic domains and the subsequent transphosphorylation of tyrosine residues in the activation loop of the kinase domain, as well as elsewhere in the intracellular domain. These phosphorylations serve to initiate further conformational changes that stabilize the active form of the enzyme as well as to provide binding sites for the enzymes and adaptor proteins that are described later.
Combined with a speciﬁc proteolytic cleavage step, mass spectroscopy can be used for peptide mass mapping. Automation of this process has made mass spectroscopy the analytic tool of choice for many proteomics projects. Monoclonal antibodies (mAbs) have been a cornerstone of protein analysis in cancer research and more recently have risen to prominence as cancer therapeutics based on their exquisite speciﬁcity for protein targets and their potent interference with protein function. Laboratory mice have been the animal model of choice for generating a ready source of diverse high-afﬁnity and high-speciﬁcity mAbs; however, the use of rodent antibodies as therapeutic agents has been restricted by the inherent immunogenicity of mouse proteins in a human setting.
RECOMMENDED TEXTS Alberts B, Johnson A, Lewis J, et al: Molecular Biology of the Cell, 4th ed. London, Taylor and Francis Group, 2002. Pecorino L: Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics. New York, Oxford University Press, 2005. Weinberg RA: Biology of Cancer. London, Garland Science, 2006. Goh KI, Cusick ME, Valle D, et al: The human disease network. Proc Natl Acad Sci USA 2007;104:8685– 8690. Hunter K: Host genetics inﬂuence tumour metastasis. Nat Rev Cancer 2006;6:141–146.