Download Advancing Prion Science: Guidance for the National Prion by Institute of Medicine, Medical Follow-Up Agency, Committee PDF

By Institute of Medicine, Medical Follow-Up Agency, Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science, Laura B. Sivitz, Rick Erdtmann

Offers a file from the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies recommending learn to shut major gaps in current wisdom of prion ailments and strategies for strengthening the U.S. study infrastructure for learning those ailments. Softcover. DNLM: Prion illnesses, prevention & control--United States.

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Extra resources for Advancing Prion Science: Guidance for the National Prion Research Program

Example text

All registered investigators involved in prion research should have access to these collections. S. Food and Drug Administration’s development of panels of reference reagents needed to evaluate the performance characteristics of tests designed to detect the prion protein and TSE infectivity. These panels would be used to confirm the performance characteristics of test kits before they are approved for public use, as well as to perform quality control on test kit lots before their release to the market.

1:3 Fund basic research to elucidate (1) the structural features of prions, (2) the molecular mechanisms of prion replication, (3) the mechanisms of pathogenesis of transmissible spongiform encephalopathies, and (4) the physiological function of PrPC. The committee believes basic research in these four areas will supply the knowledge required to advance TSE diagnostics more quickly than applied research alone. The report text describes specific gaps in knowledge that need to be filled in each of the four areas.

2002), supporting the hypothesis that blood can serve as reservoir for infectious prions. , 1994). By contrast, investigations into the transmissibility of the vCJD agent through blood transfusion are just beginning to gain momentum. Because a significant amount of prions appears in the lymphoreticular system in vCJD cases but not in other varieties of human TSEs, the blood of vCJD-infected individuals may contain prions. The amount of vCJD prions that might be contained in blood and the amount that constitutes an IU are important public health questions.

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