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By C. Meyers

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223 in a retrospective analysis from 1990 to 1999, demonstrated improved survival, an 81% risk reduction of death among HIV-infected individuals, with the initiation of HAART after the diagnosis of KS. 233 One of them is a viral homologue of human interleukin-6 (IL-6), called viral IL-6. 237,238 EPIDEMIOLOGY OF MCD The precise incidence of MCD is not known, but it has been found to be more common in HIV-infected individuals. 239 2. AIDS Malignancies 41 CLINICAL PRESENTATION OF MCD Patients with MCD often have constitutional symptoms of fever and fatigue.

Hoffmann and colleagues,44 in a retrospective analysis, showed that survival time of patients receiving HAART in addition to RT differed significantly from those receiving RT or palliative care alone. 5 years. These findings are suggestive that immune recovery is contributing to longer remission in patients studied. 54 AIDS-related NHLs are grouped into three distinct histologic categories, including small non-cleaved cell lymphoma, diffuse large-cell lymphoma, and anaplastic large-cell lymphoma.

The uneven distribution among HIV risk groups lead to the search for an infectious transmissible agent, which eventually led to the discovery of the KS herpes virus or human herpes virus-8 in 1994. 142 For further HHV-8 pathogenesis in KS, MCD, and PEL, refer to each section, respectively. 144 Four types of KS have been described: classic, endemic or African, posttransplant or iatrogenic, and AIDS-associated KS. 159–161 HHV-8 PATHOGENESIS IN KS Multiple factors contribute to the development of KS.

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