By Charles Wood Ph.D. (auth.), C. Meyers (eds.)
AIDS-associated viral oncology is an important healthcare challenge. because the identity of human immunodeficiency virus (HIV)-associated bought immune affliction syndrome (AIDS), the position of viruses in human cancers has turn into acutely obvious over the last two decades. the knowledge and remedy of AIDS-associated cancers has turn into an enormous predicament between healthcare corporations. Human cancers that have been as soon as infrequent within the inhabitants have now develop into universal in the HIV contaminated inhabitants.
Experts proportion their collective wisdom and look at the medical and organic facets, together with viruses good validated of their roles, in addition to rising new viruses. This quantity might be a source for either participants of the medical and healthcare group and energetic researchers during this field.
"Human immunodeficiency virus (HIV) - linked bought immune illness syndrome (AIDS) areas contributors at elevated hazard for virally mediated cancers. this article addresses the medical and organic points of this subject. individual investigators within the box current a complete review with relevance to laboratory scientists and training clinicians."
Steven T. Rosen, M.D.
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Extra info for Aids-Associated Viral Oncogenesis
This chapter will review available data demonstrating the effect of HAART on the epidemiology, presentation, treatment, and outcomes of HIV-associated malignancies mediated by EBV, HHV-8, and HPV. 3 Like all herpesviruses, EBV has latent and productive (lytic) phases in its life cycle, the former maintaining the virus long term in its host and the latter potentiating virus production and spread. 9 Specific T cells that target EBV-infected B cells are not decreased, but they lose their ability to respond to EBV antigens, including ones involved in virus reactivation and subsequent lymphomagenesis.
Adverse risk factors for age-adjusted IPI are: stage III or IV disease, elevated LDH, performance status ≥2. 30 AIDS-Associated Viral Oncogenesis intensive therapy (age and performance status). The simplified model for younger patients (the age-adjusted IPI) uses a subgroup of these clinical features (tumor stage, LDH level, and performance status). 88 compared the prognostic factors for survival and the use of the IPI in pre- and post-HAART HIV-infected individuals with diffuse-large cell lymphoma.
At 38 weeks 2. 261 Aaron and colleagues239 reported case histories of seven HIV-infected individuals with MCD on HAART and chemotherapy. Four had KS along with their MCD. The main causes of death in the pre-HAART studies of MCD were associated with immune deficiency from HIV disease itself, such as opportunistic infections. 150 Now it is called primary effusion lymphoma (PEL), a name more commonly used in the literature to describe this syndrome. HHV-8 AND EBV ETIOLOGY IN PEL Cesarman and colleagues150 found HHV-8 sequences among eight HIV-infected individuals with PEL, and quantitatively, these lymphomas contained 60–80 copies of HHV-8 per cells, compared with one copy in the KS lesion.